Treatment of severe refractory erythema nodosum leprosum with tumor necrosis factor inhibitor Etanercept.
نویسندگان
چکیده
Erythema nodosum leprosum (ENL) is a common complication of lepromatous leprosy. Some patients unresponsive to conventional, first-line therapeutics develop recurrent, recalcitrant ENL. Here, we report a case of severe refractory ENL that was successfully treated with Etanercept. Biologics may be considered as therapeutic alternatives in management of severe, recalcitrant ENL.
منابع مشابه
Severe refractory erythema nodosum leprosum successfully treated with the tumor necrosis factor inhibitor etanercept.
Erythema nodosum leprosum (ENL), or type II reaction, is a common complication of lepromatous leprosy that can cause significant patient debility. First-line therapy includes prednisone and thalidomide, with clofazimine reserved for patients who do not respond to first-line treatment. We present the case of a 33-year-old woman with ENL that failed to respond adequately to conventional therapy o...
متن کاملEtanercept in erythema nodosum leprosum*
One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of sid...
متن کاملOur experience of the use of thalidomide in the steroid-dependent severe erythema nodosum leprosum.
Sir, Severe, chronic, recurrent erythema nodosum leprosum (ENL) is a serious problem. Patients are in need of effective and safe treatment because there is a danger of steroid dependence. Thalidomide has been shown to be highly effective in the treatment of refractory ENLs.[1] A number of dosage regimens of thalidomide, an expensive drug, have been tried.[1-3] We describe our experience of the ...
متن کاملEffective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation.
The immunomodulatory drug thalidomide is the treatment of choice for erythema nodosum leprosum (ENL), an inflammatory cutaneous and systemic complication of multibacillary leprosy. To elucidate the mechanism of action of thalidomide in this syndrome, we prospectively investigated 20 patients with ENL who were treated with thalidomide for 21 days. All patients responded to treatment, with the ma...
متن کاملFamilial clustering of severe atypical variants of erythema nodosum leprosum in immunocompetent siblings
Erythema nodosum leprosum is characterised by brightly erythematous tender nodules or plaques usually in bilateral symmetrical distribution. ENL can also present in several atypical presentations like pustular, erythema multiform like, ulcerative, necrotic, panniculitic and bullous forms. Various precipitating factors for ENL include stress, pregnancy, surgery, lactation, menstruation, infectio...
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ورودعنوان ژورنال:
- International journal of mycobacteriology
دوره 5 2 شماره
صفحات -
تاریخ انتشار 2016